सीदन्त्यकृतकृत्या वै कालध्वस्तमनोरथा: ॥ १७ ॥
sīdanty akṛta-kṛtyā vai
ete — these; ātma-hanaḥ — killers of the self; aśāntāḥ — devoid of peace; ajñāne — in ignorance; jñāna-māninaḥ — presuming to have knowledge; sīdanti — they suffer; akṛta — failing to perform; kṛtyāḥ — their duty; vai — indeed; kāla — by time; dhvasta — destroyed; manaḥ-rathāḥ — their fanciful desires.
The killers of the soul are never peaceful, because they consider that human intelligence is ultimately meant for expanding material life. Thus neglecting their real, spiritual duties, they are always in distress. They are filled with great hopes and dreams, but unfortunately these are always destroyed by the inevitable march of time.
There is a similar verse in Śrī Īśopaniṣad (3):
tāṁs te pretyābhigacchanti
ye ke cātma-hano janāḥ
“The killer of the soul, whoever he may be, must enter into the planets known as the worlds of the faithless, full of darkness and ignorance.”